Agenda Abstracts 5


Pequod Room - Westin Maui Lahaina

Tuesday Feb 12

8 pm – 9 pm: Welcome committee and roundtable to define agenda.

Wednesday Feb 13

9:00 am – 9:30 am: Setup and introduction

Gary Goldberg (Rowan University)

9:30am - 10:00 am: Fibroblasts-dependent invasion of podoplanin-positive cancer stem cells in squamous cell carcinoma

Genichiro Ishii, Tomoyuki Miyashita (University of Tokyo and National Cancer Center Chiba)

10:00 am – 10:30 am: Targeting podoplanin-platelet interaction for suppressing tumor progression

Ai Takemoto (Japanese Foundation for Cancer Research)

10:30 am – 11:00 am: PDPN Promotes Destructive Pathways in Cancer and Arthritis

Harini Krishnan (Stony Brook University)

11:00 am – 11:30 am: Efficient detection of circulating tumor cells (CTCs) in malignant pleural mesothelioma (MPM) with "universal" CTC-chip and anti-podoplanin antibody NZ-1.2.

Kazue Yoneda (University of Occupational and Environmental Health)

11:30 am – 12:00 pm: Podoplanin targeting chimeric antigen receptor T (CAR-T) cells based on cancer specific monoclonal antibody show tumor-specific cytotoxicity against glioblastoma.

Lushun Chalise (Nagoya University)

12:00 pm – 1:30 pm: Lunch

1:30 pm – 2:00 pm: Platelet CLEC-2 upregulates podoplanin expression on macrophages and promotes their migration

Julie Rayes (University of Birmingham)

2:00 pm – 2:30 pm: The role of PDPN/CLEC-2 signaling in cutaneous allergic hypersensitivity

Miho Tsutsumi (Kyoto Prefectural University of Medicine)

2:30 pm – 3:00 pm: Regulation of T cell mediated tissue inflammation by podoplanin

Patrick Burkett (Harvard Medical School and Brigham and Women’s Hospital)

3:00 pm – 3:20 pm: Fibroblast cadherins affect podoplanin expression, Src kinase induced cell motility, and transformed cell morphology

Stephanie Sheehan (Rowan University)

3:20 pm - 3:40 pm: Novel treatment modalities inhibit Src and PDPN activity in oral cancer

Edward Retzbach (Rowan University)

3:40 pm - 4:00 pm: Combination therapy targeting podoplanin to treat oral squamous cell carcinoma

Clinton A. Timmerman (Rowan University)

4:00 pm - 5:00 pm: Roundtable to define opportunities and future planning

6:00 pm: Dinner excursion