Pequod Room – Westin Maui Lahaina
Tuesday Feb 12
8 pm – 9 pm: Welcome committee and roundtable to define agenda.
Wednesday Feb 13
9:00 am – 9:30 am: Setup and introduction
Gary Goldberg (Rowan University)
9:30am – 10:00 am: Fibroblasts-dependent invasion of podoplanin-positive cancer stem cells in squamous cell carcinoma
Genichiro Ishii, Tomoyuki Miyashita (University of Tokyo and National Cancer Center Chiba)
10:00 am – 10:30 am: Targeting podoplanin-platelet interaction for suppressing tumor progression
Ai Takemoto (Japanese Foundation for Cancer Research)
10:30 am – 11:00 am: PDPN Promotes Destructive Pathways in Cancer and Arthritis
Harini Krishnan (Stony Brook University)
11:00 am – 11:30 am: Efficient detection of circulating tumor cells (CTCs) in malignant pleural mesothelioma (MPM) with “universal” CTC-chip and anti-podoplanin antibody NZ-1.2.
Kazue Yoneda (University of Occupational and Environmental Health)
11:30 am – 12:00 pm: Podoplanin targeting chimeric antigen receptor T (CAR-T) cells based on cancer specific monoclonal antibody show tumor-specific cytotoxicity against glioblastoma.
Lushun Chalise (Nagoya University)
12:00 pm – 1:30 pm: Lunch
1:30 pm – 2:00 pm: Platelet CLEC-2 upregulates podoplanin expression on macrophages and promotes their migration
Julie Rayes (University of Birmingham)
2:00 pm – 2:30 pm: The role of PDPN/CLEC-2 signaling in cutaneous allergic hypersensitivity
Miho Tsutsumi (Kyoto Prefectural University of Medicine)
2:30 pm – 3:00 pm: Regulation of T cell mediated tissue inflammation by podoplanin
Patrick Burkett (Harvard Medical School and Brigham and Women’s Hospital)
3:00 pm – 3:20 pm: Fibroblast cadherins affect podoplanin expression, Src kinase induced cell motility, and transformed cell morphology
Stephanie Sheehan (Rowan University)
3:20 pm – 3:40 pm: Novel treatment modalities inhibit Src and PDPN activity in oral cancer
Edward Retzbach (Rowan University)
3:40 pm – 4:00 pm: Combination therapy targeting podoplanin to treat oral squamous cell carcinoma
Clinton A. Timmerman (Rowan University)
4:00 pm – 5:00 pm: Roundtable to define opportunities and future planning
6:00 pm: Dinner excursion